Well, if you don't know where it is, then you didn't lock them. Anybody else using that station? The Scratch Disk setting doesn't get saved with the project file; it's just part of the application. If another user uses your station and resets the Scratch Disk (most likely to an external), you'll have to set it for yourself.
The other option is scarier: Maybe your disk is dying. Check all drives connected to the system and make sure none of them has less than 10 per cent free space left.