Nope - but there will be a quality difference. In DVDSP you can either use the quicktime MPEG2 codec, or compressor - both of which have many settings you can use to improve the quality of the encoding.
Encoding MPEG2 can be a bit of a black art - there's often not a magic number that will produce the best results from all footage , and because you have to compress longer videos more to fit on the disc, there's always a length / quality trade-off.
Graeme